Article
A multi-marker association method for genome-wide association studies without the need for population structure correction.
Nature communications - 10 Nov 2016
Klasen Jonas R, Barbez Elke, Meier Lukas, Meinshausen Nicolai, Bühlmann Peter, Koornneef Maarten, Busch Wolfgang, Schneeberger Korbinian
Abstract excerpt
All common genome-wide association (GWA) methods rely on population structure correction, to avoid false genotype-to-phenotype associations. However, population structure correction is a stringent penalization, which also impedes identification of real associations. Using recent statistical advances, we developed a new GWA method, called Quantitative Trait Cluster Association Test (QTCAT), enabling simultaneous...
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