Article
Novel genetic matching methods for handling population stratification in genome-wide association studies.
BMC bioinformatics - 14 Mar 2015
Lacour André, Schüller Vitalia, Drichel Dmitriy, Herold Christine, Jessen Frank, Leber Markus, Maier Wolfgang, Noethen Markus M, Ramirez Alfredo, Vaitsiakhovich Tatsiana, Becker Tim
Abstract excerpt
BACKGROUND: A usually confronted problem in association studies is the occurrence of population stratification. In this work, we propose a novel framework to consider population matchings in the contexts of genome-wide and sequencing association studies. We employ pairwise and groupwise optimal c...
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