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Article

Survivin enhances hippocampal neurogenesis and cognitive function in Alzheimer's disease mouse model

30 Oct 2023

Abstract excerpt

AIMS: Cognitive impairment is associated with reduced hippocampal neurogenesis; however, the causes of decreased hippocampal neurogenesis remain highly controversial. Here, we investigated the role of survivin in the modulation of hippocampal neurogenesis in AD. METHODS: To investigate the effect of survivin on neurogenesis in neural stem cells (NSCs), we treated mouse embryonic NSCs with a survivin inhibitor...

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PMID: 37904343
DOI: 10.1111/cns.14509

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