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Effect of Soluble Amyloid Precursor Protein-alpha on Adult Hippocampal Neurogenesis in a Mouse Model of Alzheimer’s Disease

2021-10-05

Abstract excerpt

<title>Abstract</title> <p>Soluble amyloid precursor protein-alpha (sAPPα) is a regulator of neuronal and memory mechanisms, while also having neurogenic and neuroprotective effects in the brain. As adult hippocampal neurogenesis is impaired in Alzheimer’s disease, we tested the hypothesis that sAPPα delivery would rescue adult hippocampal neurogenesis in an APP/PS1 mouse model of Alzheimer’s disease. An adeno-as...

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Literature Corpus work
b0c1da83-e0ae-5337-b357-425c948f814f
DOI
10.21203/rs.3.rs-952426/v1
Open publication

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