Article
Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice.
Neurobiology of disease - 1 Jun 2002
Wen Paul H, Shao Xiang, Shao Zhiping, Hof Patrick R, Wisniewski Thomas, Kelley Kevin, Friedrich Victor L, Ho Lap, Pasinetti Giulio M, Shioi Junichi, Robakis Nikolaos K, Elder Gregory A
Abstract excerpt
Mutations in the presenilin-1 (PS-1) gene are one cause of familial Alzheimer's disease (FAD). However, the functions of the PS-1 protein as well as how PS-1 mutations cause FAD are incompletely understood. Here we investigated if neuronal overexpression of wild-type or FAD mutant PS-1 in transgenic mice affects neurogenesis in the hippocampus of adult animals. We show that either a wild-type or an FAD mutant...
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