Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mesenchymal Stem Cells Increase Hippocampal Neurogenesis and Neuronal Differentiation by Enhancing the Wnt Signaling Pathway in an Alzheimer's Disease Model.

Cell transplantation - 1 Jan 2015

Oh Se Hee, Kim Ha Na, Park Hyun-Jung, Shin Jin Young, Lee Phil Hyu

Abstract excerpt

Neurogenesis in the subgranular zone of the hippocampal dentate gyrus may act as an endogenous repair mechanism in Alzheimer's disease (AD), and the Wnt signaling pathway has been suggested to closely modulate neurogenesis in amyloid-β (Aβ)-related AD models. The present study investigated whether mesenchymal stem cells (MSCs) would modulate hippocampal neurogenesis via modulation of the Wnt signaling pathway in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to beta Catenin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bromodeoxyuridine

Share to Mesenchymal Stem Cell Transplantation

Share to Mesenchymal Stem Cells

Share to Neural Stem Cells

Share to Neurogenesis

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 24612635
DOI: 10.3727/096368914X679237

Genes

MSC
GFAP
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mesenchymal Stem Cells Increase Hippocampal Neurogenesis and Neuronal Differentiation by Enhancing the Wnt Signaling Pathway in an Alzheimer's Disease Model.PMID 24612635Read ↗

Neurogenesis, NSCs, pathogenesis and therapies for Alzheimer's disease.Semantic proximity Read ↗

Targeting neurogenesis ameliorates danger assessment in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Intranasal Delivery of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Alleviate Memory Deficits In Sporadic Alzheimer’s Rat Model By Regulating Neurotrophic and Apoptosis GenesSemantic proximity Read ↗

Intranasal Delivery of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells Alleviates Memory Deficits In Sporadic Alzheimer’s Rat Models By Regulating Neurotrophic and Apoptotic GenesSemantic proximity Read ↗

Bone marrow-derived mesenchymal stem cells contribute to the reduction of amyloid-β deposits and the improvement of synaptic transmission in a mouse model of pre-dementia Alzheimer's disease.Semantic proximity Read ↗

Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model.Semantic proximity Read ↗

Wnt signaling in the nervous system and in Alzheimer's diseaseSemantic proximity Read ↗

Ganglioside-Dependent Neural Stem Cell Proliferation in Alzheimer's Disease Model Mice.Semantic proximity Read ↗

Increased Dentate Neurogenesis After Grafting of Glial Restricted Progenitors or Neural Stem Cells in the Aging HippocampusSemantic proximity Read ↗

Adult Neurogenesis, Neural Stem Cells and Alzheimers Disease: Developments, Limitations, Problems and PromisesSemantic proximity Read ↗

Enhancing Adult Neurogenesis Rescues Hippocampal Cognitive Functions in an Alzheimer’s Mouse ModelSemantic proximity Read ↗

Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.