Article
Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model.
Hippocampus - 1 Dec 2009
Yu Yingxin, He Jue, Zhang Yanbo, Luo Huanmin, Zhu Shenghua, Yang Yi, Zhao Tou, Wu Jiang, Huang Yuangui, Kong Jiming, Tan Qingrong, Li Xin-Min
Abstract excerpt
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with senile beta-amyloid (Abeta) plaques and cognitive decline. Neurogenesis in the adult hippocampus is implicated in regulating learning and memory, and is increased in human postmortem brain of AD patients. However,...
Topics
- Aging
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Astrocytes
- Cell Differentiation
- Cell Proliferation
- DNA-Binding Proteins
- Disease Models, Animal
- Disease Progression
- Doublecortin Domain Proteins
- Glial Fibrillary Acidic Protein
- Hippocampus