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Article

Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model.

Hippocampus - 1 Dec 2009

Yu Yingxin, He Jue, Zhang Yanbo, Luo Huanmin, Zhu Shenghua, Yang Yi, Zhao Tou, Wu Jiang, Huang Yuangui, Kong Jiming, Tan Qingrong, Li Xin-Min

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with senile beta-amyloid (Abeta) plaques and cognitive decline. Neurogenesis in the adult hippocampus is implicated in regulating learning and memory, and is increased in human postmortem brain of AD patients. However, little is currently known about the changes of hippocampal neurogenesis in the progression of AD. As brain tissues...

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Source

Identifiers

PMID: 19309037
DOI: 10.1002/hipo.20587

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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