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Article

Generation of a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient carrying an E363Q mutation in PSEN1 gene.

Stem cell research - 1 May 2022

Zhu Wanwan, Zhou You, Wang Qingyu, Li Jie, Chu Shanshan, Jin Wei, Mao Chenhui, Dong Liling, Gao Jing, Xu Qi

Abstract excerpt

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by cognitive decline even leading to incapacity, which prevalence estimates that about 5% of AD cases are caused by mutations in genes such as Presenilin-1 (PSEN1). Here we report the generation and characterization of an iPSC line derived from a patient carrying an E363Q mutation in PSEN1 gene. The iPSC line we generated presented a...

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Identifiers

PMID: 35421846
DOI: 10.1016/j.scr.2022.102769

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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