A single micromanipulated stem cell gives rise to multiple T-cell receptor gene rearrangements in the thymus in vitro.

doi:10.1038/324063a0

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Article

A single micromanipulated stem cell gives rise to multiple T-cell receptor gene rearrangements in the thymus in vitro.

Nature - 1 Jan 2000

Williams G T, Kingston R, Owen M J, Jenkinson E J, Owen J J

Abstract excerpt

The extensive range of specificities of T-cell receptors is generated, as for immunoglobulins, by rearrangement of genetic information. Much valuable information about rearrangement processes has been inferred by comparing DNA from (monoclonal) lymphoid lines with germ-line DNA and, for B cells,...

Topics

Animals
Antibodies, Monoclonal
Mice
Mutation
Nucleic Acid Hybridization
Organ Culture Techniques
Receptors, Antigen, T-Cell
Thymus Gland

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