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Article

A single micromanipulated stem cell gives rise to multiple T-cell receptor gene rearrangements in the thymus in vitro.

Nature - 1 Jan 2000

Williams G T, Kingston R, Owen M J, Jenkinson E J, Owen J J

Abstract excerpt

The extensive range of specificities of T-cell receptors is generated, as for immunoglobulins, by rearrangement of genetic information. Much valuable information about rearrangement processes has been inferred by comparing DNA from (monoclonal) lymphoid lines with germ-line DNA and, for B cells, from rearrangements in some Abelson murine leukaemia virus-transformed cell lines. However, because it is difficult to...

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PMID: 3785373
DOI: 10.1038/324063a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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