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Article

Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element.

Nature - 1 Jan 2000

Clark S P, Yoshikai Y, Taylor S, Siu G, Hood L, Mak T W

Abstract excerpt

The humoral immune system antigen-binding proteins (immunoglobulins) are disulphide-linked heterodimers of light and heavy chains. The gene for the variable region which determines antigen specificity is assembled when one member from each of the dispersed clusters of variable (V) gene segments, diversity (D) elements (for the heavy chains only) and joining (J) segments rearrange and fuse during B-cell...

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PMID: 6434993
DOI: 10.1038/311387a0

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