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Article

Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element.

Nature - 1 Jan 2000

Clark S P, Yoshikai Y, Taylor S, Siu G, Hood L, Mak T W

Abstract excerpt

The humoral immune system antigen-binding proteins (immunoglobulins) are disulphide-linked heterodimers of light and heavy chains. The gene for the variable region which determines antigen specificity is assembled when one member from each of the dispersed clusters of variable (V) gene segments, diversity (D) elements (for the heavy chains only) and joining (J) segments rearrange and fuse during B-cell...

Topics

Amino Acid Sequence
Animals
Base Sequence
DNA
Genes
Genetic Variation
Humans
Immunoglobulin J-Chains
Immunoglobulin Variable Region
Macromolecular Substances
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Antigen, T-Cell

Species Specificity

Source

Identifiers

PMID: 6434993
DOI: 10.1038/311387a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6434993-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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