Article
A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations.
Nature - 1 Jan 2000
Kingston R, Jenkinson E J, Owen J J
Abstract excerpt
There is much interest in early T-cell development, particularly in relation to the diversification of the T-cell receptor repertoire and the elucidation of the lineage relationships between T-cell populations in the thymus and peripheral lymphoid organs. However, the requirements for the growth of the earliest thymic T-cell precursor in 13-14-day mouse embryo thymus in isolation from the thymic environment are...
Topics
- Animals
- Antigens, Ly
- Cell Differentiation
- Clone Cells
- Deoxyguanosine
- Hematopoietic Stem Cells
- Mice
- Mice, Inbred BALB C
- Mice, Inbred CBA
- Organ Culture Techniques
- Phenotype