Environmental and allele-specific influences on T cell receptor gene rearrangement: skewed alpha, delta, and gamma gene rearrangement patterns in chimeric mice.

doi:10.1002/eji.1830211208

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Article

Environmental and allele-specific influences on T cell receptor gene rearrangement: skewed alpha, delta, and gamma gene rearrangement patterns in chimeric mice.

European journal of immunology - 1 Dec 1991

Larché M, Manzo A R, Hurwitz J L

Abstract excerpt

This study was performed as a means to examine the effects of environment and stem cell origin on the molding of T cell receptor gene rearrangements during T cell development. Lethally irradiated adult mice were first reconstituted with (C57BL/6 x DBA/2)F1 stem cells, which derived either from a...

Topics

Alleles
Animals
Blotting, Southern
Environment
Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Genes
Hematopoietic Stem Cells
Heterozygote
Hybridomas
Mice
Mice, Inbred Strains
Radiation Chimera

Source

Open in PubMed

Identifiers

PMID: 1660810
DOI: 10.1002/eji.1830211208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1660810-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Receptors, Antigen, T-Cell, alpha-beta

Receptors, Antigen, T-Cell, gamma-delta

Thymus Gland