Article
Antigen-receptor junctional diversity in growth-factor-receptor mutant mice.
Developmental and comparative immunology - 1 Jan 2000
Rodewald H R, Haller C
Abstract excerpt
Precursor lymphocytes undergo expansion prior to immunoglobulin (Ig) or T cell receptor (TCR) rearrangements. Development of thymocytes, but not B cells, is entirely blocked in mice lacking both the receptor-tyrosine-kinase c-kit and the common cytokine receptor gamma chain (gamma c). In c-kit-gamma c-mice, TCR beta rearrangements are limited to mono- or oligoclonal DJ junctions. Here, effects of lack of c-kit or...
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