Article
Antigen-receptor junctional diversity in growth-factor-receptor mutant mice.
Developmental and comparative immunology - 1 Jan 2000
Rodewald H R, Haller C
Abstract excerpt
Precursor lymphocytes undergo expansion prior to immunoglobulin (Ig) or T cell receptor (TCR) rearrangements. Development of thymocytes, but not B cells, is entirely blocked in mice lacking both the receptor-tyrosine-kinase c-kit and the common cytokine receptor gamma chain (gamma c). In c-kit-ga...
Topics
- Animals
- Female
- Gene Rearrangement, T-Lymphocyte
- Genes, Immunoglobulin
- Genetic Variation
- Growth Substances
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Immunoglobulin delta-Chains
- Immunoglobulin gamma-Chains
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Mutant Strains
- Proto-Oncogene Proteins c-kit
- Receptors, Antigen, T-Cell, alpha-beta
- Receptors, Antigen, T-Cell, gamma-delta
- Spleen