Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse.

Genesis (New York, N.Y. : 2000) - 1 Feb 2013

Tang Michelle C W, Jacobs Shelley A, Wong Lee H, Mann Jeffrey R

Abstract excerpt

Post-translational modifications to residues in core histones convey epigenetic information. Their function can be evaluated in amino acid substitution mutants, although to date this method has not been used in mice. To this end, we have evaluated gene targeting vectors designed for Cre recombinase-mediated conditional allelic replacement at the two unlinked genes encoding the histone variant H3.3. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3' Untranslated Regions
Share to Alleles
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Targeting

Share to Histones

Share to Integrases

Share to Protein Processing, Post-Translational

Source

Identifiers

PMID: 23315948
DOI: 10.1002/dvg.22366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional allelic replacement applied to genes encoding the histone variant H3.3 in the mouse.PMID 23315948Read ↗

Genome editing a mouse locus encoding a variant histone, H3.3B, to report on its expression in live animals.Semantic proximity Read ↗

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals.Semantic proximity Read ↗

Leveraging dominant-negative histone H3 K-to-M mutations to study chromatin during differentiation and development.Semantic proximity Read ↗

A vector system encoding histone H3 mutants facilitates manipulations of the neuronal epigenome.Semantic proximity Read ↗

Transcriptional and developmental functions of the H3.3 histone variant in Drosophila.Semantic proximity Read ↗

Cartilage-Specific Cre Recombinase Transgenes/Alleles in the Mouse.Semantic proximity Read ↗

A knockout-first model of H3f3a gene targeting leads to developmental lethality.Semantic proximity Read ↗

Cre-loxP chromosome engineering of a targeted deletion in the mouse corresponding to the 3p21.3 region of homozygous loss in human tumours.Semantic proximity Read ↗

A conditional histone H3.3 mutation in mice orthologous to a driver of paediatric diffuse instrinsic pontine gliomaSemantic proximity Read ↗

Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila.Semantic proximity Read ↗

H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells.Semantic proximity Read ↗

Caution! Analyze transcripts from conditional knockout alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.