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Article

H3.3K122A results in a neomorphic phenotype in mouse embryonic stem cells.

Epigenetics & chromatin - 1 Nov 2024

Patty Benjamin J, Jordan Cailin, Lardo Santana M, Troy Kris, Hainer Sarah J

Abstract excerpt

Canonical histone H3 and histone variant H3.3 are posttranslationally modified with the genomic distribution of these marks denoting different features and these modifications may influence transcription. While the majority of posttranslational modifications occur on histone tails, there are defined modifications within the globular domain, such as acetylation of H3K122/H3.3K122. To understand the function of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39487536
DOI: 10.1186/s13072-024-00557-3
PMCID: PMC11531108

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