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Article

A vector system encoding histone H3 mutants facilitates manipulations of the neuronal epigenome.

Scientific reports - 18 Oct 2024

Warren Sophie, Xiong Sen, Robles-Magallanes Daisy, Baizabal José-Manuel

Abstract excerpt

The differentiation of developmental cell lineages is associated with genome-wide modifications in histone H3 methylation. However, the causal role of histone H3 methylation in transcriptional regulation and cell differentiation has been difficult to test in mammals. The experimental overexpression of histone H3 mutants carrying lysine-to-methionine (K-to-M) substitutions has emerged as an alternative tool for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39420029
DOI: 10.1038/s41598-024-74270-2
PMCID: PMC11487264

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