Article
Histone Lysine-to-Methionine Mutations Reduce Histone Methylation and Cause Developmental Pleiotropy.
Plant physiology - 1 Apr 2017
Sanders Dean, Qian Shuiming, Fieweger Rachael, Lu Li, Dowell James A, Denu John M, Zhong Xuehua
Abstract excerpt
Epigenetic modifications play critical roles in diverse biological processes. Histone Lys-to-Met (K-to-M) mutations act as gain-of-function mutations to inhibit a wide range of histone methyltransferases and are thought to promote tumorigenesis. However, it is largely unknown whether K-to-M mutations impact organismal development. Using Arabidopsis (Arabidopsis thaliana) as a model system, we discovered that a...
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