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Article

ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: further support for significant disease heterogeneity.

The American journal of gastroenterology - 1 Oct 2008

Fowler Elizabeth V, Doecke James, Simms Lisa A, Zhao Zhen Zhen, Webb Penelope M, Hayward Nicholas K, Whiteman David C, Florin Timothy H, Montgomery Grant W, Cavanaugh Juleen A, Radford-Smith Graham L

Abstract excerpt

OBJECTIVES: Crohn's disease (CD) and ulcerative colitis (UC) are the two most common forms of inflammatory bowel disease (IBD), representing a significant health-care burden. A variant in the autophagy gene ATG16L1 (T300A) has been newly identified as a CD susceptibility locus by genome-wide association. Our aim was to assess the contribution of T300A in determining disease susceptibility and phenotype in two...

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PMID: 18671817
DOI: 10.1111/j.1572-0241.2008.02023.x

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