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Article

Mutant SF3B1 promotes malignancy in PDAC.

eLife - 12 Oct 2023

Simmler Patrik, Ioannidi Eleonora I, Mengis Tamara, Marquart Kim Fabiano, Asawa Simran, Van-Lehmann Kjong, Kahles Andre, Thomas Tinu, Schwerdel Cornelia, Aceto Nicola, Rätsch Gunnar, Stoffel Markus, Schwank Gerald

Abstract excerpt

The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1K700E on the PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1K700E alone is insufficient to induce malignant transformation of the murine pancreas, but that it increases aggressiveness of PDAC if it co-occurs with mutated KRAS...

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Source

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Identifiers

PMID: 37823551
DOI: 10.7554/eLife.80683
PMCID: PMC10629822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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