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Article

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer

20 May 2019

Abstract excerpt

BACKGROUND: The TG-interacting factor 1 (TGIF1) gene, which encodes a nuclear transcriptional corepressor of the TGFβ1/Smad signaling pathway, has been implicated in the pathogenesis of various types of human cancer; however, its role in pancreatic ductal adenocarcinoma (PDAC) has yet to be elucidated. METHODS: The expression of TGIF1 in human and murine PDAC specimens were detected by IHC analysis. The functions...

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PMID: 31109321
DOI: 10.1186/s12943-019-1023-1

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