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Article

ID1 Mediates Escape from TGFβ Tumor Suppression in Pancreatic Cancer

3 Oct 2019

Abstract excerpt

Abstract TGFβ is an important tumor suppressor in pancreatic ductal adenocarcinoma (PDA), yet inactivation of TGFβ pathway components occurs in only half of PDA cases. TGFβ cooperates with oncogenic RAS signaling to trigger epithelial-to-mesenchymal transition (EMT) in premalignant pancreatic epithelial progenitors, which is coupled to apoptosis owing to an imbalance of SOX4 and KLF5 transcription factors. We...

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PMID: 31582374
DOI: 10.1158/2159-8290.cd-19-0529

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