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Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers.

Oncogene - 1 Jan 2021

Alsafadi Samar, Dayot Stephane, Tarin Malcy, Houy Alexandre, Bellanger Dorine, Cornella Michele, Wassef Michel, Waterfall Joshua J, Lehnert Erik, Roman-Roman Sergio, Stern Marc-Henri, Popova Tatiana

Abstract excerpt

Genes involved in 3'-splice site recognition during mRNA splicing constitute an emerging class of oncogenes. SF3B1 is the most frequently mutated splicing factor in cancer, and SF3B1 mutants corrupt branchpoint recognition leading to usage of cryptic 3'-splice sites and subsequent aberrant junctions. For a comprehensive determination of alterations leading to this splicing pattern, we performed a pan-TCGA...

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Adenocarcinoma of Lung
Codon Usage
HEK293 Cells
Loss of Heterozygosity
Phosphoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splice Sites

RNA Splicing Factors

Sequence Analysis, RNA

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Identifiers

PMID: 33057152
DOI: 10.1038/s41388-020-01507-5
PMCID: PMC7790757

Genes

SF3B1
SUGP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Genetic alterations of SUGP1 mimic mutant-SF3B1 splice pattern in lung adenocarcinoma and other cancers.PMID 33057152Read ↗

Pan-cancer analysis identifies mutations in SUGP1 that recapitulate mutant SF3B1 splicing dysregulation.Semantic proximity Read ↗

Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.Semantic proximity Read ↗

SF3B1: from core splicing factor to oncogenic driver.Semantic proximity Read ↗

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Cancer-associated SF3B1 mutants recognize otherwise inaccessible cryptic 3' splice sites within RNA secondary structures.Semantic proximity Read ↗

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