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SF3B1: from core splicing factor to oncogenic driver.

RNA (New York, N.Y.) - 19 Feb 2025

Bak-Gordon Pedro, Manley James L

Abstract excerpt

Highly recurrent somatic mutations in the gene encoding the core splicing factor SF3B1 are drivers of multiple cancer types. SF3B1 is a scaffold protein that orchestrates multivalent protein-protein interactions within the spliceosome that are essential for recognizing the branchsite (BS) and selecting the 3' splice site during the earliest stage of pre-mRNA splicing. In this review, we first describe the...

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Carcinogenesis
Neoplasms
Oncogenes
Phosphoproteins
RNA Splice Sites
RNA Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing Factors

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Identifiers

PMID: 39773890
DOI: 10.1261/rna.080368.124
PMCID: PMC11874996

Genes

SF3B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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