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Article

SF3B1 mutation in pancreatic cancer contributes to aerobic glycolysis and tumor growth through a PP2A-c-Myc axis.

Molecular oncology - 1 Nov 2021

Yang Jian-Yu, Huo Yan-Miao, Yang Min-Wei, Shen Yang, Liu De-Jun, Fu Xue-Liang, Tao Ling-Ye, He Rui-Zhe, Zhang Jun-Feng, Hua Rong, Jiang Shu-Heng, Sun Yong-Wei, Liu Wei

Abstract excerpt

Hot spot gene mutations in splicing factor 3b subunit 1 (SF3B1) are observed in many types of cancer and create abundant aberrant mRNA splicing, which is profoundly implicated in tumorigenesis. Here, we identified that the SF3B1 K700E (SF3B1K700E ) mutation is strongly associated with tumor growth in pancreatic ductal adenocarcinoma (PDAC). Knockdown of SF3B1 significantly retarded cell proliferation and tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33932092
DOI: 10.1002/1878-0261.12970
PMCID: PMC8564647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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