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A genetically encoded anti-CRISPR protein constrains gene drive spread and prevents population suppression

25 Jun 2021

Abstract excerpt

CRISPR-based gene drives offer promising means to reduce the burden of pests and vector-borne diseases. These techniques consist of releasing genetically modified organisms carrying CRISPR-Cas nucleases designed to bias their inheritance and rapidly propagate desired modifications. Gene drives can be intended to reduce reproductive capacity of harmful insects or spread anti-pathogen effectors through wild...

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PMID: 34172748
DOI: 10.1038/s41467-021-24214-5

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