TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas.

doi:10.1007/s13277-015-4694-2

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Article

TERT promoter hot spot mutations are frequent in Indian cervical and oral squamous cell carcinomas.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jun 2016

Vinothkumar Vilvanathan, Arunkumar Ganesan, Revathidevi Sundaramoorthy, Arun Kanagaraj, Manikandan Mayakannan, Rao Arunagiri Kuha Deva Magendhra, Rajkumar Kottayasamy Seenivasagam, Ajay Chandrasekar, Rajaraman Ramamurthy, Ramani Rajendren, Murugan Avaniyapuram Kannan, Munirajan Arasambattu Kannan

Abstract excerpt

Squamous cell carcinoma (SCC) of the uterine cervix and oral cavity are most common cancers in India. Telomerase reverse transcriptase (TERT) overexpression is one of the hallmarks for cancer, and activation through promoter mutation C228T and C250T has been reported in variety of tumors and often shown to be associated with aggressive tumors. In the present study, we analyzed these two hot spot mutations in 181...

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PMID: 26700669
DOI: 10.1007/s13277-015-4694-2

Genes

TERT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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