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Article

Genetic basis of murine antibacterial defense to streptococcal lung infection.

Immunogenetics - 1 Sept 2007

Hollingsworth John W, Whitehead Gregory, Berman Katherine Gray, Tekippe Erin McElvania, Gilmour M Ian, Larkin Jennie E, Quackenbush John, Schwartz David A

Abstract excerpt

To evaluate the effect of genetic background on antibacterial defense to streptococcal infection, eight genetically diverse strains of mice (A/J, DBA/2J, CAST/Ei, FVB/NJ, BALB/cJ, C57BL/6J, 129/SvImJ, and C3H/HeJ) and tlr2-deficient mice (C57BL/6(tlr2-/-)) were infected with three doses of Streptococcus zooepidemicus (500, 5,000, or 50,000 colony-forming units) by alveolar challenge. There was a range of...

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PMID: 17701033
DOI: 10.1007/s00251-007-0242-6

Genes

CAST
TLR2

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