Article

Effects of different environments and microbial exposures on the adult immune system of the C57BL/6 laboratory mouse strain

2025-10-22

Abstract excerpt

<h4>ABSTRACT</h4> The realization that the grossly underdeveloped immune system of laboratory mice may hinder their use as suitable models of human disease has led to the development of different strategies to “normalize” immune responses in these mice so that they more closely resemble those typical of the human population. In this study, we performed a comprehensive comparison of the adult immune systems and mi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14d33214-bc56-53e0-b9e7-4ed7817046bf
DOI: 10.1101/2025.10.22.683895

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of different environments and microbial exposures on the adult immune system of the C57BL/6 laboratory mouse strainDOI 10.1101/2025.10.22.683895Read

Normalizing the environment recapitulates adult human immune traits in laboratory mice.Semantic proximity Read

A gavage-fomite based method to generate mouse models with natural microbiotaSemantic proximity Read

Naturalizing mouse models for immunology.Semantic proximity Read

Composition of Intestinal Microbiota in Immune-Deficient Mice Kept in Three Different Housing ConditionsSemantic proximity Read

Laboratory mice with a wild microbiota generate strong allergic immune responsesSemantic proximity Read

Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotypeSemantic proximity Read

Housing laboratory mice deficient for <i>Nod2</i> and <i>Atg16l1</i> in a natural environment uncovers genetic and environmental contributions to immune variationSemantic proximity Read

Microbial considerations in genetically engineered mouse research.Semantic proximity Read

Natural versus Laboratory World: Incorporating Wild-Derived Microbiota into Preclinical Rodent ModelsSemantic proximity Read

A Multigenerational “Dirty” Mouse Model for Studying Trauma-Induced Immune Dysregulation and Infection SusceptibilitySemantic proximity Read

Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humansSemantic proximity Read

The ecology of immune state in a wild mammal, Mus musculus domesticus.Semantic proximity Read