Article
Genetic control of susceptibility to Candida albicans in SM/J mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2014
Radovanovic Irena, Leung Vicki, Iliescu Alexandra, Bongfen Silayuv E, Mullick Alaka, Langlais David, Gros Philippe
Abstract excerpt
In the immunocompromised host, invasive infection with the fungal pathogen Candida albicans is associated with high morbidity and mortality. Sporadic cases in otherwise normal individuals are rare, and they are thought to be associated with genetic predisposition. Using a mouse model of systemic infection with C. albicans, we identified the SM/J mouse strain as unusually susceptible to infection. Genetic linkage...
Topics
- Animals
- Antigens, Ly
- Candidiasis
- Chemokine CCL2
- Disease Models, Animal
- Disease Susceptibility
- Female
- Genetic Predisposition to Disease
- Heterogeneous-Nuclear Ribonucleoprotein Group A-B
- Immunophenotyping
- Inflammation
- Male
- Membrane Proteins