Article
Association of apoptosis-related variants to malaria infection and parasite density in individuals from the Brazilian Amazon.
Malaria journal - 4 Oct 2023
Sena-Dos-Santos Camille, Cavalcante Giovanna C, Marques Diego, Silva Caio S, de Moraes Milene Raiol, Pinto Pablo, Santana-da-Silva Mayara Natália, Ferraz Rafaella S, Costa Sheyla Patrícia T, Ventura Ana Maria R, Póvoa Marinete M, Cunha Maristela G, Ribeiro-Dos-Santos Ândrea
Abstract excerpt
BACKGROUND: In malaria infection, apoptosis acts as an important immunomodulatory mechanism that leads to the elimination of parasitized cells, thus reducing the parasite density and controlling immune cell populations. Here, it was investigated the association of INDEL variants in apoptotic genes-rs10562972 (FAS), rs4197 (FADD), rs3834129 and rs59308963 (CASP8), rs61079693 (CASP9), (CASP3), ...