Article
A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria.
PLoS genetics - 1 May 2011
Schuldt Kathrin, Kretz Cosima C, Timmann Christian, Sievertsen Jürgen, Ehmen Christa, Esser Claudia, Loag Wibke, Ansong Daniel, Dering Carmen, Evans Jennifer, Ziegler Andreas, May Jürgen, Krammer Peter H, Agbenyega Tsiri, Horstmann Rolf D
Abstract excerpt
Human genetics and immune responses are considered to critically influence the outcome of malaria infections including life-threatening syndromes caused by Plasmodium falciparum. An important role in immune regulation is assigned to the apoptosis-signaling cell surface receptor CD95 (Fas, APO-1), encoded by the gene FAS. Here, a candidate-gene association study including variant discovery at the FAS gene locus...
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