Article
Deletion of the APOBEC3B gene strongly impacts susceptibility to falciparum malaria.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2012
Jha Pankaj, Sinha Swapnil, Kanchan Kanika, Qidwai Tabish, Narang Ankita, Singh Prashant Kumar, Pati Sudhanshu S, Mohanty Sanjib, Mishra Saroj K, Sharma Surya K, Awasthi Shally, Venkatesh Vimala, Jain Sanjeev, Basu Analabha, Xu Shuhua, Mukerji Mitali, Habib Saman
Abstract excerpt
APOBEC3B, a gene involved in innate response, exhibits insertion-deletion polymorphism across world populations. We observed the insertion allele to be nearly fixed in malaria endemic regions of sub-Saharan Africa as well as populations with high malaria incidence in the past. This prompted us to investigate the possible association of the polymorphism with falciparum malaria. We studied the distribution of...
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