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Article

Germline alterations in patients with lung cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2026

Govindan R, Navo K, Huang M, Liu J, Chao C, Zong X, Sankararaman S, Bolton K, Cao Y

Abstract excerpt

BACKGROUND: Germline alterations and smoking status in lung cancer could inform etiology and clinical decisions. We investigated the prevalence of germline alterations in predisposition genes across various lung cancer histologies in two large populations. PATIENTS AND METHODS: Germline sequencing of 11 740 primary lung cancers was carried out with Tempus xT tumor-normal matched assay (DNA sequencing of 648 genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41412497
DOI: 10.1016/j.annonc.2025.12.008

Genes

MUTYH
ATM
BRCA2
EGFR
CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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