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Article

Biological and therapeutic implications of the cancer-related germline mutation landscape in lung cancer.

The Lancet. Respiratory medicine - 1 Dec 2024

Panagiotou Emmanouil, Vathiotis Ioannis A, Makrythanasis Periklis, Hirsch Fred, Sen Triparna, Syrigos Konstantinos

Abstract excerpt

Although smoking is the primary cause of lung cancer, only about 15% of lifelong smokers develop the disease. Moreover, a substantial proportion of lung cancer cases occur in never-smokers, highlighting the potential role of inherited genetic factors in the cause of lung cancer. Lung cancer is significantly more common among those with a positive family history, especially for early-onset disease. Therefore, the...

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Identifiers

PMID: 38885686
DOI: 10.1016/S2213-2600(24)00124-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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