Comprehensive omics studies of p53 mutants in human cancer.

Abstract excerpt

The p53 is the master regulator of the cell known for regulating a large array of cellular processes. Inactivation of p53 by missense mutations is one of the leading causes of cancer. Some of these mutations endow p53 with selective oncogenic functions to promote tumor progression. Due to the vast array of mutations found in p53, the experimental studies showing the role of different mutant p53 as an oncogene are...

Topics

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• Mutation
• Mutation, Missense
• Neoplasms
• Oncogenes
• Tumor Suppressor Protein p53