Phenotypical mapping of TP53 unique missense mutations spectrum in human cancers.

Abstract excerpt

The p53 tumor suppressor is one of the most mutated genes responsible for tumorigenesis in most human cancers. Out of 29,891 genomic mutations reported in the TP53 Database (https://tp53.isb-cgc.org/), 1,297 are identified as unique missense somatic mutations excluding frameshift, intronic, deletion, nonsense, silent, splice, and other unknown mutations. We have comprehensively analyzed all these 1,297 unique...

Topics

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• Databases, Genetic
• TP53 gene
• Mutation, Missense
• Neoplasms
• Phenotype