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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.

Human mutation - 1 Jun 2007

Petitjean Audrey, Mathe Ewy, Kato Shunsuke, Ishioka Chikashi, Tavtigian Sean V, Hainaut Pierre, Olivier Magali

Abstract excerpt

The tumor suppressor gene TP53 is frequently mutated in human cancers. More than 75% of all mutations are missense substitutions that have been extensively analyzed in various yeast and human cell assays. The International Agency for Research on Cancer (IARC) TP53 database (www-p53.iarc.fr) compiles all genetic variations that have been reported in TP53. Here, we present recent database developments that include...

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Identifiers

PMID: 17311302
DOI: 10.1002/humu.20495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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