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Article

Aging-disturbed FUS phase transition impairs hematopoietic stem cells by altering chromatin structure.

Blood - 11 Jan 2024

Tang Baixue, Wang Xinming, He Hanqing, Chen Ruiqing, Qiao Guofeng, Yang Yang, Xu Zihan, Wang Longteng, Dong Qiongye, Yu Jia, Zhang Michael Q, Shi Minglei, Wang Jianwei

Abstract excerpt

ABSTRACT: Aged hematopoietic stem cells (HSCs) exhibit compromised reconstitution capacity. The molecular mechanisms behind this phenomenon are not fully understood. Here, we observed that the expression of FUS is increased in aged HSCs, and enforced FUS recapitulates the phenotype of aged HSCs through arginine-glycine-glycine-mediated aberrant FUS phase transition. By using Fus-gfp mice, we observed that FUShigh...

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Identifiers

PMID: 37748139
DOI: 10.1182/blood.2023020539

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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