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Article

LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells

7 Nov 2018

Abstract excerpt

BACKGROUND: The decline of hematopoietic stem cell (HSC) function upon aging contributes to aging-associated immune remodeling and leukemia pathogenesis. Aged HSCs show changes to their epigenome, such as alterations in DNA methylation and histone methylation and acetylation landscapes. We previously showed a correlation between high Cdc42 activity in aged HSCs and the loss of intranuclear epigenetic polarity, or...

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PMID: 30404662
DOI: 10.1186/s13059-018-1557-3

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