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Article

DNA methylation drives hematopoietic stem cell aging phenotypes after proliferative stress.

GeroScience - 1 Apr 2025

Yanai Hagai, McNeely Taylor, Ayyar Saipriya, Leone Michael, Zong Le, Park Bongsoo, Beerman Isabel

Abstract excerpt

Aging of hematopoietic stem cells (HSCs) is implicated in various aging phenotypes, including immune dysfunction, anemia, and malignancies. The role of HSC proliferation in driving these aging phenotypes, particularly under stress conditions, remains unclear. Therefore, we induced forced replications of HSCs in vivo by a cyclical treatment with low-dose fluorouracil (5FU) and examined the impact on HSC aging. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39390312
DOI: 10.1007/s11357-024-01360-4
PMCID: PMC11978565

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