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Article

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.

PLoS biology - 1 Aug 2007

Chambers Stuart M, Shaw Chad A, Gatza Catherine, Fisk C Joseph, Donehower Lawrence A, Goodell Margaret A

Abstract excerpt

Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan. Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we demonstrate a deficit in function yet an increase in stem cell number with advancing age. Expression analysis of more than 14,000 genes identified 1,500 that were age-induced and 1,600 that were age-repressed. Genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17676974
DOI: 10.1371/journal.pbio.0050201
PMCID: PMC1925137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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