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Article

PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation.

Science signaling - 4 Nov 2014

Mackey Ashley M, Sarkes Deborah A, Bettencourt Ian, Asara John M, Rameh Lucia E

Abstract excerpt

Phosphatidylinositol-5-phosphate 4-kinases (PIP4ks) are a family of lipid kinases that specifically use phosphatidylinositol 5-monophosphate (PI-5-P) as a substrate to synthesize phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. Suppression of PIP4k function in Drosophila results in smaller cells and reduced target of rapamycin complex 1 (TORC1) signaling. We showed that the γ isoform of PIP4k stimulated...

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Identifiers

PMID: 25372051
DOI: 10.1126/scisignal.2005191
PMCID: PMC4579097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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