Article

Lithium treatment drives coordinated multi-kinase remodelling of the mouse synaptic phosphoproteome

2026-07-31

Abstract excerpt

<title>Abstract</title> <p>Lithium is the gold standard mood stabiliser used to treat cycling mania and depression in bipolar disorder. Despite seven decades of clinical use, the mechanisms of its mood stabilisation are incompletely understood, fundamentally limiting development of improved alternatives. Two established lithium targets, glycogen synthase kinase 3β (GSK3β) and inositol monophosphatase, both modula...

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Literature Corpus work: 5b75c3a6-b3d1-5122-a6cb-eae947a35341
DOI: 10.21203/rs.3.rs-9945220/v1

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