Article

Identification And Computational Characterization Of Novel Genetic Variants Associated With Alzheimer's Disease Using Bioinformatics And Machine Learning

2026-08-22

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, amyloid-beta (Aβ) accumulation, neuroinflammation, oxidative stress, and neuronal dysfunction. Microglia–astrocyte interactions play an important role in modulating Aβ-associated cellular responses and neuroprotection. The present study aimed to computationally identify and characterize candidate genetic varian...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c78ad89e-d15c-53cc-a38a-8a18c9b5b951
DOI: 10.5281/zenodo.22057543

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification And Computational Characterization Of Novel Genetic Variants Associated With Alzheimer's Disease Using Bioinformatics And Machine LearningDOI 10.5281/zenodo.22057543Read

Identification And Computational Characterization Of Novel Genetic Variants Associated With Alzheimer's Disease Using Bioinformatics And Machine LearningSemantic proximity Read

Functional characterization of Alzheimer's disease genetic variants in microglia.Semantic proximity Read

The ONDRISeq panel: custom-designed next-generation sequencing of genes related to neurodegenerationSemantic proximity Read

Brain Region-Dependent Alternative Splicing of Alzheimer Disease (AD)-Risk Genes Is Associated With Neuropathological Features in ADSemantic proximity Read

Associations of Alzheimer’s disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegenerationSemantic proximity Read

Common and Rare Genetic Variants Associated With Alzheimer's Disease.Semantic proximity Read

Linking non-coding variants to function in microglia in Alzheimer's disease.Semantic proximity Read

Leveraging functional annotations to map rare variants associated with Alzheimer’s disease with gruyereSemantic proximity Read

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics.Semantic proximity Read

Leveraging functional annotations to map rare variants associated with Alzheimer disease with gruyere.Semantic proximity Read

Rare coding variants from ADSP R5 whole-genome sequencing implicate novel genes in Alzheimer’s diseaseSemantic proximity Read

Targeted Sequencing of Alzheimer Disease Genes in African Americans Implicates Novel Risk VariantsSemantic proximity Read