Article
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.
The Journal of clinical investigation - 15 Nov 2023
Chen Zhihong, Giotti Bruno, Kaluzova Milota, Vallcorba Montse Puigdelloses, Rawat Kavita, Price Gabrielle, Herting Cameron J, Pinero Gonzalo, Cristea Simona, Ross James L, Ackley James, Maximov Victor, Szulzewsky Frank, Thomason Wes, Marquez-Ropero Mar, Angione Angelo, Nichols Noah, Tsankova Nadejda M, Michor Franziska, Shayakhmetov Dmitry M, Gutmann David H, Tsankov Alexander M, Hambardzumyan Dolores
Abstract excerpt
Monocytes and monocyte-derived macrophages (MDMs) from blood circulation infiltrate glioblastoma (GBM) and promote growth. Here, we show that PDGFB-driven GBM cells induce the expression of the potent proinflammatory cytokine IL-1β in MDM, which engages IL-1R1 in tumor cells, activates the NF-κB pathway, and subsequently leads to induction of monocyte chemoattractant proteins (MCPs). Thus, a feedforward paracrine...
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