Article
The role of IL-1β in the early tumor cell-induced angiogenic response.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2013
Carmi Yaron, Dotan Shahar, Rider Peleg, Kaplanov Irena, White Malka R, Baron Rona, Abutbul Shai, Huszar Monica, Dinarello Charles A, Apte Ron N, Voronov Elena
Abstract excerpt
In this study, we assessed the involvement of IL-1β in early angiogenic responses induced by malignant cells using Matrigel plugs supplemented with B16 melanoma cells. We found that during the angiogenic response, IL-1β and vascular endothelial growth factor (VEGF) interact in a newly described autoinduction circuit, in which each of these cytokines induces the other. The IL-1β and VEGF circuit acts through...
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