Article

Spatial patterning and immunosuppression of glioblastoma immune contexture in hypoxic niches

2022-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM), a highly lethal brain cancer, is notorious for its immunosuppressive microenvironment, yet current immunotherapies are ineffective. Thus, understanding the immune contexture and governing factors of immunosuppression is crucial. Here, we identified a highly dynamic temporospatial patterning of tumor-associated macrophages (TAMs) corresponding to vascular changes in GBM: as tu...

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Literature Corpus work: f4e5667d-1a1c-51ad-b27d-d4a3267f95c0
DOI: 10.1101/2022.03.01.482530

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