Article

PI3K signaling promotes inflammatory tumor-macrophage crosstalk associated with mesenchymal glioblastoma

2026-07-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Glioblastoma (GBM) is a highly heterogeneous and vascularized malignancy in which the mesenchymal (MES) subtype is associated with poor prognosis, extensive macrophage infiltration and resistance to therapy. However, the signaling mechanisms integrating vascular remodeling with inflammatory tumor-macrophage crosstalk remain incompletely understood. <h4>Methods</h4> We integ...

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Literature Corpus work: f9ce1600-35b1-5bf5-8836-5f7fe0446a1c
DOI: 10.64898/2026.07.27.738732

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