Article
Allele specific binding of histone modifications and a transcription factor does not predict allele specific expression in correlated ChIP-seq peak-exon pairs.
Scientific reports - 20 Sept 2023
Prowse-Wilkins Claire P, Wang Jianghui, Garner Josie B, Goddard Michael E, Chamberlain Amanda J
Abstract excerpt
Allele specific expression (ASE) is widespread in many species including cows. Therefore, regulatory regions which control gene expression should show cis-regulatory variation which mirrors this differential expression within the animal. ChIP-seq peaks for histone modifications and transcription factors measure activity at functional regions and the height of some peaks have been shown to correlate across tissues...
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