Article

Putative bovine topological association domains and CTCF binding motifs can reduce the search space for causative regulatory variants of complex traits

2018-01-04

Abstract excerpt

<h4>Background</h4> Topological association domains (TADs) are chromosomal domains characterised by frequent internal DNA-DNA interactions. The transcription factor CTCF binds to conserved DNA sequence patterns called CTCF binding motifs to either prohibit or facilitate chromosomal interactions. TADs and CTCF binding motifs control gene expression, but they are not yet well defined in the bovine genome. In this p...

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Literature Corpus work: 106563d8-bfb0-53cb-b2f3-4a9854374d14
DOI: 10.1101/242792

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